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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FEN1
All Species:
28.48
Human Site:
S255
Identified Species:
56.97
UniProt:
P39748
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P39748
NP_004102.1
380
42593
S255
D
L
I
Q
K
H
K
S
I
E
E
I
V
R
R
Chimpanzee
Pan troglodytes
XP_001149490
346
39044
C235
I
L
L
G
S
D
Y
C
E
S
I
R
G
I
G
Rhesus Macaque
Macaca mulatta
XP_001118506
412
46252
C301
I
L
L
G
S
D
Y
C
E
S
I
R
G
I
G
Dog
Lupus familis
XP_533271
380
42605
S255
D
L
I
Q
K
H
K
S
I
E
E
I
V
R
R
Cat
Felis silvestris
Mouse
Mus musculus
P39749
378
42296
S253
D
L
I
Q
K
H
K
S
I
E
E
I
V
R
R
Rat
Rattus norvegicus
NP_445882
380
42603
S255
D
L
I
Q
K
H
K
S
I
E
E
I
V
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001072959
381
42965
T255
E
L
I
K
Q
H
K
T
I
E
E
I
I
Q
H
Frog
Xenopus laevis
P70040
382
42650
T255
D
L
I
R
Q
H
K
T
I
D
E
I
I
D
N
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523765
385
42930
D255
E
L
I
N
T
Y
R
D
I
E
T
I
L
D
N
Honey Bee
Apis mellifera
XP_395769
379
42891
T255
E
L
I
K
T
H
R
T
L
E
K
I
I
E
N
Nematode Worm
Caenorhab. elegans
NP_491168
382
42531
N255
E
L
I
R
Q
H
K
N
I
E
T
I
L
E
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P26793
382
43261
S253
K
L
I
K
T
H
G
S
I
E
K
I
V
E
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91
83.2
98.1
N.A.
95.5
95.7
N.A.
N.A.
84.2
79.8
N.A.
N.A.
62.5
62.3
61.2
N.A.
Protein Similarity:
100
91
83.9
99.2
N.A.
97.1
98.4
N.A.
N.A.
93.1
90.8
N.A.
N.A.
78.9
80.2
76.6
N.A.
P-Site Identity:
100
6.6
6.6
100
N.A.
100
100
N.A.
N.A.
53.3
53.3
N.A.
N.A.
33.3
33.3
46.6
N.A.
P-Site Similarity:
100
13.3
13.3
100
N.A.
100
100
N.A.
N.A.
93.3
86.6
N.A.
N.A.
60
80
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
56.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
72.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
17
0
0
0
0
0
0
0
% C
% Asp:
42
0
0
0
0
17
0
9
0
9
0
0
0
17
0
% D
% Glu:
34
0
0
0
0
0
0
0
17
75
50
0
0
25
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
0
0
0
17
0
0
9
0
0
0
0
0
17
0
17
% G
% His:
0
0
0
0
0
75
0
0
0
0
0
0
0
0
9
% H
% Ile:
17
0
84
0
0
0
0
0
75
0
17
84
25
17
0
% I
% Lys:
9
0
0
25
34
0
59
0
0
0
17
0
0
0
0
% K
% Leu:
0
100
17
0
0
0
0
0
9
0
0
0
17
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
9
0
0
0
0
0
0
34
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
34
25
0
0
0
0
0
0
0
0
9
0
% Q
% Arg:
0
0
0
17
0
0
17
0
0
0
0
17
0
34
34
% R
% Ser:
0
0
0
0
17
0
0
42
0
17
0
0
0
0
0
% S
% Thr:
0
0
0
0
25
0
0
25
0
0
17
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
42
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
17
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _